Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. In Swine, IVOMEC Injection is formulated to deliver the recommended dose level of 300 mcg ivermectin/kilogram body weight when given subcutaneously in the neck at the rate of 1 mL per 75 lb (33 kg). IVOMEC Injection is formulated to deliver the recommended dose level of 200 mcg ivermectin/kilogram of body weight in cattle when given subcutaneously at the rate of 1 mL/110 lb (50 kg). IVOMEC Injection is a clear, ready-to-use, sterile solution containing 1% ivermectin, 40% glycerol formal, and propylene glycol, q.s. Ivermectin is derived from the avermectins, a family of potent, broadspectrum antiparasitic agents isolated from fermentation of Streptomyces avermitilis. Its convenience, broad-spectrum efficacy, and safety margin make IVOMEC Injection a unique product for parasite control of cattle and swine. Discovered and developed by scientists from Merck Research Laboratories, ivermectin is a novel chemical entity. One low-volume dose effectively treats and controls the following internal and external parasites that may impair the health of cattle and swine: gastrointestinal roundworms (including inhibited Ostertagia ostertagi in cattle), lungworms, grubs, sucking lice, and mange mites of cattle and gastrointestinal roundworms, lungworms, lice, and mange mites of swine. IVOMEC ® (ivermectin) is an injectable parasiticide for cattle and swine. ![]() ![]() ![]() A Parasiticide for the Treatment and Control of Internal and External Parasites of Cattle and SwineĬonsult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
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